The Rhode Island Child Health Study

year of publication: 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023

2023

• Variation in placental microRNA expression associates with maternal family history of cardiovascular disease. 

  Tehrani JM, Kennedy EM, Tian FY, Everson TM, Deyssenroth M, Burt A, Hermetz K, Hao K, Chen J, Koestler DC, Marsit CJ.J Dev Orig Health Dis. 2023 Feb;14(1):132-139. doi: 10.1017/S2040174422000319. Epub 2022 Jul 11.PMID: 35815737 

2022

• Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts. 

  Tian FY, Kennedy EM, Hermetz K, Burt A, Everson TM, Punshon T, Jackson BP, Hao K, Chen J, Karagas MR, Koestler DC, Marsit C. Epigenetics. 2022 Oct;17(10):1234-1245. doi: 10.1080/15592294.2021.2003044. Epub 2021 Nov 16.PMID: 34784848 

• Placental Gene Transcript Proportions are Altered in the Presence of In Utero Arsenic and Cadmium Exposures, Genetic Variants, and Birth Weight Differences

  Deyssenroth MA, Peng S, Hao K, Marsit CJ, Chen J. Front Genet. 2022 May 13;13:865449. doi: 10.3389/fgene.2022.865449. PMID: 35646058; PMCID: PMC9136297.

• Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth

  Tehrani JM, Kennedy E, Tung PW, Burt A, Hermetz K, Punshon T, Jackson BP, Hao K, Chen J, Karagas MR, Koestler DC, Lester B, Marsit CJ. Pediatr Res. 2022 Jul 29:10.1038/s41390-022-02201-w. doi: 10.1038/s41390-022-02201-w. PMID: 35906307; PMCID: PMC9884320.

• Association between placental toxic metal exposure and NICU Network Neurobehavioral Scales (NNNS) profiles in the Rhode Island Child Health Study (RICHS)

  Tung PW, Burt A, Karagas M, Jackson BP, Punshon T, Lester B, Marsit CJ. Environ Res. 2022 Mar;204(Pt A):111939. doi: 10.1016/j.envres.2021.111939.

• Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study

  Tung PW, Burt A, Karagas M, Jackson BP, Punshon T, Lester B, Marsit CJ. Environ Epidemiol. 2022 Jan 28;6(1):e194. doi: 10.1097/EE9.0000000000000194.

• PM 2.5 exposure during pregnancy is associated with altered placental expression of lipid metabolic genes in a US birth cohort

  Kaur K, Lesseur C, Deyssenroth MA, Kloog I, Schwartz JD, Marsit CJ, Chen J. Environ Res. 2022 Aug;211:113066. doi: 10.1016/j.envres.2022.113066.

2021

• Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.

  Everson TM, Vives-Usano M, Seyve E, Cardenas A, Lacasaña M, Craig JM, Lesseur C, Baker ER, Fernandez-Jimenez N, Heude B, Perron P, Gónzalez-Alzaga B, Halliday J, Deyssenroth MA, Karagas MR, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke YJ, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández MF, Tost J, Gómez-Martín A, London SJ, Sunyer J, Marsit CJ, Lepeule J, Hivert MF, Bustamante M. Nat Commun. 2021 Aug 24;12(1):5095. doi: 10.1038/s41467-021-24558-y.

• Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study

  Howe CG, Foley HB, Kennedy EM, Eckel SP, Chavez TA, Faham D, Grubbs BH, Al-Marayati L, Lerner D, Suglia S, Bastain TM, Marsit CJ, Breton CV. Epigenetics. 2022 Mar;17(3):269-285. doi: 10.1080/15592294.2021.1899887.

• Placental gene networks at the interface between maternal PM 2.5 exposure early in gestation and reduced infant birthweight

  Deyssenroth MA, Rosa MJ, Eliot MN, Kelsey KT, Kloog I, Schwartz JD, Wellenius GA, Peng S, Hao K, Marsit CJ, Chen J. Environ Res. 2021 Aug;199:111342. doi: 10.1016/j.envres.2021.111342.

2020

• Placental MicroRNA Expression Associates With Birthweight Through Control of Adipokines: Results from Two Independent Cohorts.

  Kennedy EM, Hermetz K, Burt A, Everson TM, Deyssenroth M, Hao K, Chen J, Karagas MR, Pei D, Koestler DC, Marsit CJ. Epigenetics. 2020 Oct 4:1-13. doi: 10.1080/15592294.2020.1827704. Epub ahead of print.

• Social Stress-Related Epigenetic Changes Associated With Increased Heart Rate Variability in Infants.

  Aghagoli G, Conradt E, Padbury JF, Sheinkopf SJ, Tokadjian H, Dansereau LM, Tronick EZ, Marsit CJ, Lester BM. Front Behav Neurosci. 2020 Jan 15;13:294. doi: 10.3389/fnbeh.2019.00294.

• Associations of Maternal Diet and Placenta Leptin Methylation.

  Daniels TE, Sadovnikoff AI, Ridout KK, Lesseur C, Marsit CJ, Tyrka AR. Mol Cell Endocrinol. 2020 Apr 5;505:110739. doi: 10.1016/j.mce.2020.110739. Epub 2020 Jan 29.

• Copper Associates With Differential Methylation in Placentae From Two US Birth Cohorts.

  Kennedy E, Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ. Epigenetics. 2020 Mar;15(3):215-230. doi: 10.1080/15592294.2019.1661211. Epub 2019 Sep 4.

• In-depth Characterization of the Placental Imprintome Reveals Novel Differentially Methylated Regions Across Birth Weight Categories.

  Deyssenroth MA, Marsit CJ, Chen J, Lambertini L. Epigenetics. 2020 Jan-Feb;15(1-2):47-60. doi: 10.1080/15592294.2019.1647945. Epub 2019 Aug 12.

• Placental lncRNA Expression Associated With Placental Cadmium Concentrations and Birth Weight.

  Hussey MR, Burt A, Deyssenroth MA, Jackson BP, Hao K, Peng S, Chen J, Marsit CJ, Everson TM. Environ Epigenet. 2020 May 10;6(1):dvaa003. doi: 10.1093/eep/dvaa003.

• Selenium-associated DNA Methylation Modifications in Placenta and Neurobehavioral Development of Newborns: An Epigenome-Wide Study of Two U.S. Birth Cohorts.

  Tian FY, Everson TM, Lester B, Punshon T, Jackson BP, Hao K, Lesseur C, Chen J, Karagas MR, Marsit CJ. Environ Int. 2020 Apr;137:105508. doi: 10.1016/j.envint.2020.105508. Epub 2020 Jan 31.

• Seasonally Variant Gene Expression in Full-Term Human Placenta.

  Clarkson-Townsend DA, Kennedy E, Everson TM, Deyssenroth MA, Burt AA, Hao K, Chen J, Pardue MT, Marsit CJ. FASEB J. 2020 Jun 23. doi: 10.1096/fj.202000291R. Epub ahead of print.

2019

• Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated With Placental Cadmium Concentrations and Birth Size.

  Everson TM, Marable C, Deyssenroth MA, Punshon T, Jackson BP, Lambertini L, Karagas MR, Chen J, Marsit CJ. Environ Health Perspect. 2019 May;127(5):57005. doi: 10.1289/EHP4264.

• Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children.

  Tomlinson MS, Lu K, Stewart JR, Marsit CJ, O'Shea TM, Fry RC. Clin Microbiol Rev. 2019 May 1;32(3). pii: e00103-18. doi: 10.1128/CMR.00103-18. Print 2019 Jun 19. Review.

• Maternal circadian disruption is associated with variation in placental DNA methylation.

  Clarkson-Townsend DA, Everson TM, Deyssenroth MA, Burt AA, Hermetz KE, Hao K, Chen J, Marsit CJ. PLoS One. 2019 Apr 26;14(4):e0215745. doi: 10.1371/journal.pone.0215745. eCollection 2019.

• Epigenome-wide Analysis Identifies Genes and Pathways Linked to Neurobehavioral Variation in Preterm Infants.

  Everson TM, Marsit CJ, Michael O'Shea T, Burt A, Hermetz K, Carter BS, Helderman J, Hofheimer JA, McGowan EC, Neal CR, Pastyrnak SL, Smith LM, Soliman A, DellaGrotta SA, Dansereau LM, Padbury JF, Lester BM. Sci Rep. 2019 Apr 19;9(1):6322. doi: 10.1038/s41598-019-42654-4.

• Maternal swimming pool exposure during pregnancy in relation to birth outcomes and cord blood DNA methylation among private well users.

  Salas LA, Baker ER, Nieuwenhuijsen MJ, Marsit CJ, Christensen BC, Karagas MR. Environ Int. 2019 Feb;123:459-466. doi: 10.1016/j.envint.2018.12.017. Epub 2019 Jan 5.

2018

• Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network.

Deyssenroth MA, Gennings C, Liu SH, Peng S, Hao K, Lambertini L, Jackson BP, Karagas MR, Marsit CJ, Chen J. Environ Int. 2018 Nov;120:373-381. doi: 10.1016/j.envint.2018.08.010. Epub 2018 Aug 17.

• Integrating-Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.

Everson TM, Marsit CJ. Curr Environ Health Rep. 2018 Sep;5(3):328-337. doi: 10.1007/s40572-018-0204-1. Review.

• Birthweight in infants conceived through in vitro fertilization following blastocyst or cleavage-stage embryo transfer: a national registry study.

Litzky JF, Boulet SL, Esfandiari N, Zhang Y, Kissin DM, Theiler RN, Marsit CJ. J Assist Reprod Genet. 2018 Jun;35(6):1027-1037. doi: 10.1007/s10815-018-1168-7. Epub 2018 Apr 10.

• Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth.

Litzky JF, Deyssenroth MA, Everson TM, Lester BM, Lambertini L, Chen J, Marsit CJ. Pediatr Res. 2018 May;83(5):1075-1083. doi: 10.1038/pr.2018.27. Epub 2018 Apr 11.

• Effect of frozen/thawed embryo transfer on birthweight, macrosomia, and low birth weight rates in US singleton infants.

Litzky JF, Boulet SL, Esfandiari N, Zhang Y, Kissin DM, Theiler RN, Marsit CJ. Am J Obstet Gynecol. 2018 Apr;218(4):433.e1-433.e10. doi: 10.1016/j.ajog.2017.12.223. Epub 2017 Dec 29.

• Roadmap for investigating epigenome deregulation and environmental origins of cancer.

Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. Int J Cancer. 2018 Mar 1;142(5):874-882. doi: 10.1002/ijc.31014. Epub 2017 Sep 13. Review.

• Epigenetic mechanisms in the placenta related to infant neurodevelopment.

Lester BM, Marsit CJ. Epigenomics. 2018 Mar 1;10(3):321-333. doi: 10.2217/epi-2016-0171. Epub 2018 Jan 30.

• Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts.

Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ. Environ Health Perspect. 2018 Jan 22;126(1):017010. doi: 10.1289/EHP2192.

2017

• Maternal residential air pollution and placental imprinted gene expression.

  Kingsley SL, Deyssenroth MA, Kelsey KT, Awad YA, Kloog I, Schwartz JD, Lambertini L, Chen J, Marsit CJ, Wellenius GA. Environ Int. 2017 Nov;108:204-211. doi: 10.1016/j.envint.2017.08.022. Epub 2017 Sep 5.

• Expression of placental regulatory genes is associated with fetal growth.

  Deyssenroth MA, Li Q, Lacasaña M, Nomura Y, Marsit C, Chen J. J Perinat Med. 2017 Oct 26;45(7):887-893. doi: 10.1515/jpm-2017-0064.

• Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes.

  Everson TM, Kappil M, Hao K, Jackson BP, Punshon T, Karagas MR, Chen J, Marsit CJ. Environ Res. 2017 Oct;158:233-244. doi: 10.1016/j.envres.2017.06.016. Epub 2017 Jul 3.

• Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases.

  Peng S, Deyssenroth MA, Di Narzo AF, Lambertini L, Marsit CJ, Chen J, Hao K. Hum Mol Genet. 2017 Sep 1;26(17):3432-3441. doi: 10.1093/hmg/ddx265.

• Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation.

  Appleton AA, Jackson BP, Karagas M, Marsit CJ. Epigenetics. 2017 Aug;12(8):607-615. doi: 10.1080/15592294.2017.1320637. Epub 2017 May 26.

• Placental imprinting variation associated with assisted reproductive technologies and subfertility.

  Litzky JF, Deyssenroth MA, Everson TM, Armstrong DA, Lambertini L, Chen J, Marsit CJ. Epigenetics. 2017 Aug;12(8):653-661. doi: 10.1080/15592294.2017.1336589. Epub 2017 Jun 16.

• Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth.

  Deyssenroth MA, Peng S, Hao K, Lambertini L, Marsit CJ, Chen J. BMC Genomics. 2017 Jul 10;18(1):520. doi: 10.1186/s12864-017-3878-0

• Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.

  Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Environ Health Perspect. 2017 Apr;125(4):511-526. doi: 10.1289/EHP595. Epub 2017 Mar 31.

2016

• Maternal cadmium, placental PCDHAC1, and fetal development.

  Everson TM, Armstrong DA, Jackson BP, Green BB, Karagas MR, Marsit CJ. Reprod Toxicol. 2016 Oct;65:263-271. doi: 10.1016/j.reprotox.2016.08.011. Epub 2016 Aug 17.

• Maternal smoking during pregnancy is associated with mitochondrial DNA methylation.

  Armstrong DA, Green BB, Blair BA, Guerin DJ, Litzky JF, Chavan NR, Pearson KJ, Marsit CJ. Environ Epigenet. 2016 Aug 1;2(3). pii: dvw020. doi: 10.1093/eep/dvw020. Epub 2016 Oct 20.

• Regions of variable DNA methylation in human placenta associated with newborn neurobehavior.

  Paquette AG, Houseman EA, Green BB, Lesseur C, Armstrong DA, Lester B, Marsit CJ. Epigenetics. 2016 Aug 2;11(8):603-13. doi: 10.1080/15592294.2016.1195534. Epub 2016 Jul 1

• Prenatal Stress, Fearfulness, and the Epigenome: Exploratory Analysis of Sex Differences in DNA Methylation of the Glucocorticoid Receptor Gene.

  Ostlund BD, Conradt E, Crowell SE, Tyrka AR, Marsit CJ, Lester BM. Front Behav Neurosci. 2016 Jul 12;10:147. doi: 10.3389/fnbeh.2016.00147. eCollection 2016.

• The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning.

  Conradt E, Hawes K, Guerin D, Armstrong DA, Marsit CJ, Tronick E, Lester BM. Child Dev. 2016 Jan-Feb;87(1):73-85. doi: 10.1111/cdev.12483.

2015

• Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment.

  Paquette AG, Lester BM, Lesseur C, Armstrong DA, Guerin DJ, Appleton AA, Marsit CJ.

  Epigenomics. 2015 Aug;7(5):767-79. doi: 10.2217/epi.15.28. Epub 2015 Sep 7.

• Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth.

  Ciesielski TH, Marsit CJ, Williams SM. BMC Pregnancy Childbirth. 2015 Aug 25;15:192. doi: 10.1186/s12884-015-0627-8.

• Select Prenatal Environmental Exposures and Subsequent Alterations of Gene-Specific and Repetitive Element DNA Methylation in Fetal Tissues.

  Green BB, Marsit CJ. Curr Environ Health Rep. 2015 Jun;2(2):126-36. doi: 10.1007/s40572-015-0045-0. Review.

• Expression of imprinted genes in placenta is associated with infant neurobehavioral development.

  Green BB, Kappil M, Lambertini L, Armstrong DA, Guerin DJ, Sharp AJ, Lester BM, Chen J, Marsit CJ. Epigenetics. 2015;10(9):834-41. doi: 10.1080/15592294.2015.1073880. Epub 2015 Jul 22.

• Placental expression profile of imprinted genes impacts birth weight.

  Kappil MA, Green BB, Armstrong DA, Sharp AJ, Lambertini L, Marsit CJ, Chen J. Epigenetics. 2015;10(9):842-9. doi: 10.1080/15592294.2015.1073881. Epub 2015 Jul 17.

• DNA methylation changes in the placenta are associated with fetal manganese exposure.

  Maccani JZ, Koestler DC, Houseman EA, Armstrong DA, Marsit CJ, Kelsey KT. Reprod Toxicol. 2015 Nov;57:43-9. doi: 10.1016/j.reprotox.2015.05.002. Epub 2015 May 15.

• Cell-composition effects in the analysis of DNA methylation array data: a mathematical perspective.

  Houseman EA, Kelsey KT, Wiencke JK, Marsit CJ. BMC Bioinformatics. 2015 Mar 21;16:95. doi: 10.1186/s12859-015-0527-y.

• The Role of Placental 11-Beta Hydroxysteroid Dehydrogenase Type 1 and Type 2 Methylation on Gene Expression and Infant Birth Weight.

  Green BB, Armstrong DA, Lesseur C, Paquette AG, Guerin DJ, Kwan LE, Marsit CJ. Biol Reprod. 2015 Jun;92(6):149. doi: 10.1095/biolreprod.115.128066. Epub 2015 Mar 18.

• Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes.

  Maccani JZ, Koestler DC, Lester B, Houseman EA, Armstrong DA, Kelsey KT, Marsit CJ.

  Environ Health Perspect. 2015 Jul;123(7):723-9. doi: 10.1289/ehp.1408561. Epub 2015 Mar 6.

• Influence of environmental exposure on human epigenetic regulation.

  Marsit CJ. J Exp Biol. 2015 Jan 1;218(Pt 1):71-9. doi: 10.1242/jeb.106971. Review.

2014

• Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior.

  Appleton AA, Lester BM, Armstrong DA, Lesseur C, Marsit CJ. Psychoneuroendocrinology. 2015 Feb;52:32-42. doi: 10.1016/j.psyneuen.2014.11.004. Epub 2014 Nov 10.

• Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort.

  Paquette AG, Lester BM, Koestler DC, Lesseur C, Armstrong DA, Marsit CJ. PLoS One. 2014 Aug 12;9(8):e104913. doi: 10.1371/journal.pone.0104913. eCollection 2014.

• The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes.

  Paquette AG, Marsit CJ. J Cell Biochem. 2014 Dec;115(12):2065-72. doi: 10.1002/jcb.24883. Review.

• Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation.

  Lesseur C, Armstrong DA, Paquette AG, Li Z, Padbury JF, Marsit CJ. Am J Obstet Gynecol. 2014 Dec;211(6):654.e1-9. doi: 10.1016/j.ajog.2014.06.037. Epub 2014 Jun 19.

• Quantitative reconstruction of leukocyte subsets using DNA methylation.

  Accomando WP, Wiencke JK, Houseman EA, Nelson HH, Kelsey KT. Genome Biol. 2014 Mar 5;15(3):R50. doi: 10.1186/gb-2014-15-3-r50.

• Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research.

  Armstrong DA, Lesseur C, Conradt E, Lester BM, Marsit CJ. FASEB J. 2014 May;28(5):2088-97. doi: 10.1096/fj.13-238402. Epub 2014 Jan 29.

2013

• Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age.

  Maccani JZ, Koestler DC, Houseman EA, Marsit CJ, Kelsey KT. Epigenomics. 2013 Dec;5(6):619-30. doi: 10.2217/epi.13.63.

• The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior.

  Conradt E, Lester BM, Appleton AA, Armstrong DA, Marsit CJ. Epigenetics. 2013 Dec;8(12):1321-9. doi: 10.4161/epi.26634. Epub 2013 Oct 17

• Patterning in placental 11-B hydroxysteroid dehydrogenase methylation according to prenatal socioeconomic adversity.

  Appleton AA, Armstrong DA, Lesseur C, Lee J, Padbury JF, Lester BM, Marsit CJ. PLoS One. 2013 Sep 5;8(9):e74691. doi: 10.1371/journal.pone.0074691. eCollection 2013.

• Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors.

  Lesseur C, Armstrong DA, Paquette AG, Koestler DC, Padbury JF, Marsit CJ. Mol Cell Endocrinol. 2013 Dec 5;381(1-2):160-7. doi: 10.1016/j.mce.2013.07.024. Epub 2013 Jul 30.

• Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero.

  Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ. Environ Health Perspect. 2013 Aug;121(8):971-7. doi: 10.1289/ehp.1205925. Epub 2013 Jun 11.

• Epigenetic basis for the development of depression in children.

  Lester BM, Conradt E, Marsit CJ. Clin Obstet Gynecol. 2013 Sep;56(3):556-65. doi: 10.1097/GRF.0b013e318299d2a8.